【Abstract】 Objective To study curative efficacy of rosuvastatin combined with metoprolol sustained release tablets in treatment of chronic heart failure and its effects on serum ET1, NO, VEGF and CRP levels. Methods 92 patients of chronic renal failure received therapy from January 2015 to January 2017 in our hospital were selected. According to random number table, those patients were divided into the observation group (n=46) and the control group (n=46). On the basis of conventional treatment, the control group was treated with metoprolol sustained release tablets, while the observation group was combined with rosuvastatin, they were treated continuously for 3 months. The changes of serum ET1, NO, VEGF, CRP, heart function and 6min walking distance were compared between the two groups before and after treatment, and clinical efficacy was compared. Results After treatment, the serum ET1 and CRP levels in the two groups were significantly lower than those before treatment, and serum NO and VEGF levels significantly increased(P＜005), the serum ET1 and CRP levels in the observation group were significantly lower than those in the control group, and the serum NO and VEGF levels were significantly higher than those in the control group(P＜005); after treatment, the left ventricular end diastolic diameter (LVEDD) and the left ventricular end systolic diameter (LVESD) in the two groups were significantly lower than those before treatment, the left ventricular ejection fraction (LVEF) significantly increased(P＜005), the LVEDD and LVESD in the observation group were significantly lower than those in the control group, and LVEF was significantly higher than those in the control group(P＜005); after treatment, the 6min walking distance in two groups was significantly increased than those before treatment(P＜005), the 6min walking distance in observation group was longer than those in the control group(P＜005); the total effective rate in the observation group was significantly higher than those in the control group((P＜005). Conclusion Rosuvastatin combined with metoprolol sustained release tablets is well for chronic renal failure, which can effectively improve the heart function and motor function, it’s intrinsic mechanism is related to the effective regulation of serum ET1, NO, VEGF and CRP expression.