【Abstract】 Objective To investigate the effect of hyperbaric oxygen combined with pancreatic kininogenase on retinal blood flow and vascular endothelial growth factor (VEGF) in elderly diabetic retinopathy（DR）patients. Methods〓146 elderly patients with DR in our hospital were selected and divided into 2 groups. 73 cases were in the control group treated with pancreatic kininogenase. 73 cases were in the experiment group treated with hyperbaric oxygen on the basis of control group. The retinal hemodynamic parameters, serum VEGF, insulinlike growth factor (IGF1), basic fibroblast growth factor (bFGF) levels, and serum levels of inflammatory cytokines, clinical efficacy and incidence of adverse reaction were compared. Results〓The effective rate in the control group (6781%) was lower than that in the experiment group (7877%), and the difference was statistically significant (P＜ 005). Compared with the control group, the levels of VPS and VED in the central retinal artery were higher. The level of RI was lower after treatment in the experiment group. The levels of serum VEGF, IGF1 and bFGF were lower after treatment. The levels of serum hypersensitivity C reactive protein (hsCRP), interleukin6 (IL6) were lower after treatment, with significant difference (P＜005). The adverse reactions included Stomach upset, dizziness, ringing in the ears and tiredness, and there was no significant difference in the incidence of adverse reactions between the two groups（P＞005）. Conclusion〓Hyperbaric oxygen combined with pancreatic kininogenase can effectively improve the retinal hemodynamic indexes in elderly patients with DR, reduce serum VEGF, IGF1, bFGF and inflammatory cytokine levels, inhibit the proliferation of blood vessels and inflammatory response, and the clinical efficacy and safety are good.  pancreatic kininogenase on retinal blood flow and VEGF in elderly diabetic retinopathy patients 【Abstract】〓Objective〓To investigate the effect of hyperbaric oxygen combined with pancreatic kininogenase on retinal blood flow and vascular endothelial growth factor (VEGF) in elderly diabetic retinopathy（DR）patients. Methods〓146 elderly patients with DR in our hospital were selected and divided into 2 groups. 73 cases were in the control group treated with pancreatic kininogenase. 73 cases were in the experiment group treated with hyperbaric oxygen on the basis of control group. The retinal hemodynamic parameters, serum VEGF, insulinlike growth factor (IGF1), basic fibroblast growth factor (bFGF) levels, and serum levels of inflammatory cytokines, clinical efficacy and incidence of adverse reaction were compared. Results〓The effective rate in the control group (6781%) was lower than that in the experiment group (7877%), and the difference was statistically significant (P＜ 005). Compared with the control group, the levels of VPS and VED in the central retinal artery were higher. The level of RI was lower after treatment in the experiment group. The levels of serum VEGF, IGF1 and bFGF were lower after treatment. The levels of serum hypersensitivity C reactive protein (hsCRP), interleukin6 (IL6) were lower after treatment, with significant difference (P＜005). The adverse reactions included Stomach upset, dizziness, ringing in the ears and tiredness, and there was no significant difference in the incidence of adverse reactions between the two groups（P＞005）. Conclusion〓Hyperbaric oxygen combined with pancreatic kininogenase can effectively improve the retinal hemodynamic indexes in elderly patients with DR, reduce serum VEGF, IGF1, bFGF and inflammatory cytokine levels, inhibit the proliferation of blood vessels and inflammatory response, and the clinical efficacy and safety are good.