【Abstract】 Objective To study clinical efficacy of DLthioctic acid on Type 2 diabetes peripheral neuropathy. Methods〓124 patients of Type 2 diabetes peripheral neuropathy from June 2014 to November 2016 in our hospital were divided into observation group and control group. The control group was treated with routine treatment, while the observation group was treated with DLthioctic acid. The clinical efficacy and TSS scores of all patients before and after treatment were observed. The nerve conduction velocity before and after the treatment, sensory nerve conduction velocity and Apoa, sVCAM1, 8ISOPGF2α, blood pressure, blood lipid, blood sugar level changes were observed. Results〓The clinical curative effect of observation group was obviously higher than that of control group (P＜ 005). The nerve conduction speed and serum apoa of the two groups after treatment were higher than that before treatment. TSS score and serum sVCAM 1 and 8iso PGF2αof the two groups after treatment were lower than that before treatment (P＜ 005). The nerve conduction speed and serum Apoa of the observation group were higher than that of control group. TSS score, serum sVCAM 1 and 8iso PGF2αof the observation group were lower than that of control group(P＜ 005). Before and after treatment, the blood pressure and blood glucose levels in both groups were significantly different (P＞005). The total cholesterol levels were significantly reduced after the treatment group (P＜ 005). Conclusion〓DLthioctic acid can reduce oxidative stress and fade disorder, improve endothelial inflammatory lesions, reduce serum sVCAM 1 and 8iso PGF2αlevel and improve the clinical symptoms and nerve conduction speed of patients with peripheral neuropathy of type 2 diabetes.