【Abstract】 Objective To investigate the effects of salvianolate and losartan on renal function, coagulation function and vascular endothelial function in elderly patients with diabetic nephropathy (DN). Methods 120 patients with senile DN admitted to our hospital from October 2016 to October 2017 were selected and divided into two groups, each with 60 cases. The control group received routine medical treatment and losartan tablets. Based on the treatment of control group, the observation group received the salvianolate. The clinical efficacy and renal function［serum creatinine (SCr), urea nitrogen (BUN), 24hour urinary protein (24h Upro)］, coagulation function［activated partial thromboplastin time (APTT), plasma fibrinogen (FIB), Plasma Prothrombin Time (PT)］, endothelial function［Nitric Oxide (NO), Endothelin1 (ET1), Vascular Hemophilia Factor (vWF)］, serum inflammatory factors［Highsensitivity Creactive protein (hsCRP), tumor necrosis factorα (TNFα), interleukin6 (IL6)］and blood lipids［triglycerides (TG), total cholesterol (TC), Lowdensity lipoprotein cholesterol (LDLC), highdensity lipoprotein cholesterol (HDLC)］, and other related indicators change before and after treatment were compared between the two groups. Results After treatment, the total effective rate in the observation group was significantly higher than that in the control group (8667% vs 6000%, 2=10909, P=0001). The levels of SCr, BUN, 24h Upro, FIB, PT, ET1, vWF, hsCRP, TNFα, IL6, TG, TC, and LDLC were decreased in both groups after treatment (P＜005), and the decreasing level was more obvious in the observation group than in the control group (P＜005). The APTT, NO, and HDLC levels were increased in both groups (P＜005), and the increasing level was more obvious in the observation group than in the control group (P＜005). Conclusion The salvianolate combined with losartan can significantly ameliorate the renal function, fibrinolytic activity and endothelial function, and effectively reduce the level of inflammatory factors for senile DN patients.