【Abstract】 Objective To measure the influence of CEACAM1 in expression of inflammatory factors, cell migration and proliferation of HBE cells, and discuss the role of CEACAM1 in bronchial epithelial cells under inflammatory environment. Methods The expression of inflammatory factors including interleukin6 (IL6), interleukin8 (IL8), transforming growth factorβ (TGFβ), vascular endothelial growth factor (VEGF) in HBE cells treated with IFNγ were measured by Realtime PCR, and the upregulated factors were selected. The siRNA interfered the expression of CEACAM1 in HBE cells to observe the role of CEACAM1 in upregulation of inflammatory factors. In HBE cells were transfected with siRNACEACAM1. We also measured cell migration speed through wound healing assay, and measured cell proliferation rate by using Cell Counting Kit8 (CCK8). Results After the stimulation by IFNγ for 24 hours, the expression levels of IL6 and IL8 were up regulated in HBE cells. No significant change of TGFβ or VEGF expression was detected, and no expression of MCP1 could be measured in HBE by Realtime PCR. As compared with the negative control group, the expression levels of both IL6 and IL8 were down regulated in HBE cells transfected with siRNACEACAM1 after IFNγ stimulation. The woundhealing assay showed a delay of cell migration in HBE cells transfected with siRNACEACAM1. The cell proliferation rate also showed a decrease in HBE cells transfected with siRNACEACAM1 according to the result of CCK8 test. Conclusion IFNγ could induce the expression of IL6 and IL8 by up regulating CEACAM1. CEACAM1 contributed to the cell migration and proliferation of HBE cells.