【Abstract】 Objective To investigate the relationship between the peroperative lymphocyte to monocyte ratio (LMR) and clinical feature and prognosis of Intrahepatic Cholangiocarcinoma (ICC). Methods We collected the patients who had diagnosed as intrahepatic cholangiocarcinoma and underwent resection between 2010 to 2017. The LMR was firstly analyzed with Area Under Receiver Operating Characteristic Curve (AUROC) and got the cutoff value. The patients were divided into two groups by the cutoff value. Then we compared the clinical feature and prognosis indictors of the two groups. Finally the COX regression analysis was used to confirm the independent risk factors for the survival of ICC. Results 105 patients had involved in our study. The ROC curve demonstrated that 341 was the cutoff value. Then 47 patients had assigned to the low LMR group and 58 were distributed to the high LMR group. The low LMR group had larger tumor diameter, later TNM stage and T stage, higher lymph node metastasis rate, higher CA199 level, and inferior overall survival time and disease survival time. The COX regression demonstrated that positive incision, lymph node metastasis, lymphvascular invasion and LMR was the independent risk factors for the survival of ICC. Conclusion LMR is an independent risk factors for the survival of ICC and can serve as an effective indictor for the prognosis of ICC.