Abstract:【Abstract】 Objective To observe the effects of lowdose urokinase combined with low molecular heparin on postoperative deep venous thrombosis (DVT) formation in patients with hypercoagulable gynecological tumor. Methods 140 patients with hypercoagulable gynecological tumor treated with surgery in our hospital were numbered according to the order of admission and then divided into the observation group (single) and the control group (double) with 70 cases in each group. The control group was given low molecular heparin, and the observation group was given lowdose urokinase combined with low molecular heparin. The levels of coagulation system molecular［fibrinogen (Fbg), Ddimer (DD), von Willebrand factor (vWF), antithrombin complex (TAT), antithrombin (AT)］, prothrombin time (PT) and activated partial thromboplastin time (APTT), platelet aggregation rate, lower limb circumference value and blood flow velocity, complications and DVT incidence rate were measured and compared between the 2 groups at 1h and 7 d after operation. Results At 7d after operation, the levels of Fbg, DD, vWF, TAT and platelet aggregation rate in the observation group were significantly lower than those in the control group (P<005), and AT level was significantly higher than that in the control group (P<005). The PT and APTT in the observation group were significantly longer than those in the control group (P<005), and the lower limb circumference value and the blood flow velocity were significantly better than those of the control group (P<005). The total incidence rate of postoperative complications and the incidence of DVT in the observation group were significantly lower than those in the control group［(143% vs.10%) and (0%vs.571%)］ (P<005). Conclusion Lowdose urokinase combined with low molecular heparin can significantly improve i coagulation function, effectively inhibit platelet aggregation, and optimize lower limb blood flow and reduce DVT risk with less complications in patients with hypercoagulable gynecological tumor.
