术前血小板/淋巴细胞计数比与卵巢癌满意肿瘤细胞减灭术的相关性分析
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四川省科技厅项目(2015JY0056);南充市科学技术和知识产权局项目(14A0098)


Association of the preoperative platetolymphocyte ratio with optimal debulking surgery in patients with ovarian cancer
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    摘要:

    【摘要】 目的 探讨血小板/淋巴细胞计数比(PLR)与卵巢癌(OC)满意肿瘤细胞减灭术(ODS)的相关性。方法 回顾分析2007年5月~2017年5月川北医学院第二临床医学院228例初始为手术治疗的卵巢癌患者的临床病理资料。采用卡方检验或t检验比较ODS和不满意肿瘤细胞减灭术(SODS)两组OC患者的临床病理特征;采用单因素、多因素二分类logistic回归分析影响卵巢癌ODS的可能因素;绘制PLR预测卵巢癌ODS的受试者工作特征(ROC)曲线,确定PLR预测卵巢癌ODS的最佳临界值,并按照PLR最佳临界值,对OC患者进行分组,并采用统计学比较两组患者的总生存期(OS)。结果 228例卵巢癌病人中,105例行ODS,123例行SODS。多因素分析提示PLR、血清CA125、恶性腹水与卵巢癌ODS存在相关性(P=0021,P=0007,P<00001)。根据ROC曲线,PLR预测卵巢癌ODS的最佳临界值为182,并据此将OC患者分高低PLR组,其中高PLR组(PLR>182)OC患者103例,低(PLR≤182)OC患者125例,两组患者的中位生存时间分别为39个月和70个月,二者比较,差异有统计学意义(χ2=31387,P<00001)。结论 作为外周血液炎性指标之一,术前外周血PLR与卵巢癌ODS相关,PLR(≤182)可作为卵巢癌初治时能否完成ODS的独立预测指标。

    Abstract:

    【Abstract】 Objective TO investigate the correlation between preoperative platelettolymphocyte ratio (PLR) and optimal debulking surgery (ODS)in ovarian cancer (OC).Methods Clinicopathological data of 228 OC patients whose initial treatment were surgical treatment and underwent surgical resection in the Second Clinical Medical School of North Sichuan Medical College from May 2007 to May 2017 were analyzed. The clinicopathological characteristics of two groups of OC patients with suboptimal debulking surgery (SODS) and ODS were analyzed by chisquare test or t test. Univariate and multivariate analyses were performed to evaluate the clinical factors affecting ODS with binary logistic regression. The receiver operating characteristic (ROC) curve of PLR predicting ODS in OC was drawn. The optimal cutoff value of PLR predicting ODS of patients with OC was determined by ROC curve, and the OC patients were categorized into two group according to the optimal cutoff value of PLR. The overall survival (OS) of the 2 groups patients were compared statistically.Results Of 228 OC patients, 105 cases were underwent ODS, and 123 were underwent SODS. PLR,serum CA125,malignant ascites were valuable factors to predict ODS in OC(P=0021,P=0007,P<00001).According to the ROC curve of PLR predicting ODS, the optimal cutoff value of PLR predicting ODS in OC patients was 182. Accordingly, all the 228 OC patients were categorized into the high PLR group (PLR>182, n=103) and low PLR group (PLR≤182, n=125). The OS patients of low PLR group was 70 months, which was obviously longer than that of high PLR group 39 months, and the difference was statistically significant(χ2=31387,P<00001).Conclusion As one of preoperative inflammatory index in peripheral blood, the preoperative PLR is related to the ODS of OC.PLR can be used as a predictive factor for ODS in the initial treatment of OC.

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  • 在线发布日期: 2018-09-19
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