【Abstract】 Objective To understand the status and risk factors of population aged ≥40 years in Chengdu Yingmenkou and lotus pond community and provide scientific basis for the establishment of standardized stroke prevention and control interventions.Methods 6050 residents of the Yingkou entrance and Lotus pond community were selected. The questionnaire survey and physical examination were carried out. Further laboratory tests and neck vascular ultrasound were implemented in the high risk group of stroke. The results could be analyzed by data processing and statistical analysis. Results 1116 highrisk groups were screened out, with a detection rate of 1845%. The risk factors of cerebral stroke in highrisk population proportio were hypertension (629%), hyperlipidemia (5591% ), obese or overweight (4794%), less exercise (4409%), smoking (3620%), diabetes (3486%), family history of stroke (2294% ), stroke history (824% ), atrial fibrillation or valvular heart disease (296%). There were significant differences in the distribution of highrisk groups between men and women ( 2=21555,P＜0001). Despite of the obesity or overweight, less exercise, diabetes, and past stroke history, the other risk factors were different. There was a statistically significant difference between genders (P＜005, P＜001). The treatment of patients with high blood lipids and atrial fibrillation was very low among the highrisk groups. Among the highrisk group, 165 respondents were in low serum Hcy group (1914%). 425 respondents were in group Hcy (493%). 272 respondents were in high Hcy group (3155%). In the highrisk group of stroke, carotid ultrasound examination revealed intimal thickening in 217 patients (5398%), 314(7811%) respondents with carotid artery plaques, and308 respondents (7662%) with carotid artery stenosis. Conclusion It is very important to early identify highrisk groups with stroke, strengthen health management, control highrisk factors, actively carry out health education,promote healthy life andimplement the prevention and treatment of stroke.