右美托咪定复合罗哌卡因腹横平面阻滞用于剖宫产术后镇痛的效果
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四川省卫生和计划生育委员会科研课题(17PJ226)


Effect of dexmedetomidine added to ropivacaine on ultrasound guided transversus abdominis plane block for postoperative analgesia after cesarean section
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    摘要:

    【摘要】 目的 探讨右美托咪定(DEX)复合罗哌卡因行腹横平面阻滞(transversus abdominis plane block,TAPB)用于剖宫产患者术后镇痛的效果。方法 选取于2016年8月~2017年1月在医院接受剖宫产术的产妇100例,随机分为DEX组产妇(D组)50例和对照组产妇(C组)50例,两组术后在超声引导下行双侧TAPB;D组产妇注射1ug/kg DEX+025%罗哌卡因共60ml;C组产妇则注射025%罗哌卡因共60ml,两组均行静脉自控镇痛(PCIA),观察并记录两组患者行双侧TAPB后到首次按压镇痛泵的时间,术后4、8、12、24和48h产妇的疼痛VAS评分、BCS舒适度评分、术后48h内PCIA按压次数及不良反应发生率。结果 两组产妇均未观察到TAPB相关并发症。D组产妇行TAPB后到首次按压镇痛泵的时间明显长于C组(P<005);与C组比较,D组术后8h、12h、24h的VAS评分降低,BCS评分升高(P<005);除行TAPB后到术后4h时间段外,其余各相邻时点间镇痛泵按压次数D组明显少于C组(P<005)。结论 采用1ug/kg DEX复合025%的罗哌卡因行TAPB可以为剖宫产妇提供更为理想的术后多模式镇痛效果,还能减少术后阿片类药物用量,且安全有效。

    Abstract:

    【Abstract】 Objective To identify the effect of dexmedetomidine added to ropivacaine on ultrasoundguided transversus abdominis plane block for postoperative analgesia after cesarean section. Methods 100 parturient women underwent cesarean sections from August 2016 to January 2017 were randomly divided into group D and group C. Bilateral TAPB was completed with totally 60ml 025% ropivacaine and 1ug/kg dexmedetomidine for group D and only totally 60ml 025% ropivacaine for group C. Patient—controlled IV analgesic(PCIA) pumps were started at the end of surgery. Time elapsed for the first additional analgesia request was recorded and VAS and BCS score, frequency of PCIA pressed at 4, 8, 12, 24 and 48 h after operation and adverse reaction were also compared. Results Patients in both groups had no TAPBrelated complication. The time elapsed for the first additional analgesia request in group D were significantly higher than that in group C(P<005). Compared with group C, VAS score were significantly low and BCS score was significantly high at postoperative 8, 12, 24h(P<005). The frequency of PCIA pressed in group C were significantly lower than that in group D at 48h, 812h, 1224h, 2448h time intervals (P<005). Conclusion Adding 1ug/kg dexmedetomidine to 025% ropivacaine in TAPB potentiats the analgesic properties of ropivacaine, reduces sufentanil consumption and safely provides good pain control after cesarean section.

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  • 在线发布日期: 2018-05-10
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