【Abstract】 Objective To study the status and influencing factors of pulmonary function among children in Tibet and provide scientific evidence for diagnosis and prevention of lung diseases in children living at high altitude. Methods 937 children aged 614 years were randomly selected from three different elevation areas in this study. Means and standard deviation were used to describe characteristics of anthropometric measures and lung function outcomes, stratified on gender and population groups. Linear regression was done to model the relations between the covariates and lung function values by altitude of residence, the analysis took into account factors that may influence lung function. Results The height, weight, chest circumference and lung function values were higher in boys than girls in the same age group (P＜005). The height, weight, and chest circumference increase with increasing altitude, at the same time, it also increased with altitude. Before adjustment for factors of gender, age, height, weight, and chest circumference, children living at lower altitude had higher lung function values than children living at higher altitude. After adjustment the situation is just the opposite, children living at higher altitude had higher lung function values than children living at lower altitude. All comparisons were statistically significant different between those four groups (P＜005). Conclusion The lung function values increase with increasing altitude. A possible explanation of these findings could be longterm adaptation to high altitude. In addition, sex, height, weight and chest circumference may influence lung function.