【Abstract】 Objective To observe the clinical application of montelukast sodium combined with terbutaline in cough variant asthma (CVA) children and analyze the level of pulmonary function, inflammatory factor and T lymphocyte subsets. Methods 90 patients with CVA were randomly divided into control group (n=45) and observation group (n=45) according to the lottery method. Both groups were treated with routine therapy. On this basis, the control group was given terbutaline atomization solution. The observation group was given montelukast sodium chewable tablet on the basis of the control group. The levels of pulmonary function, serum inflammatory factors and T lymphocyte subsets were measured in all subjects. Results There was no significant difference in lung function between the two groups before treatment (P＞005). After treatment, the levels of FEV1 and PEF in both groups were significantly higher than those before treatment (P＜005). The observation group was significantly higher than the control group, and the difference was significant (P＜005). There was no significant difference in FVC level between the two groups before and after treatment (P＞005). There was no significant difference in the level of inflammatory factors between the two groups before treatment (P＞005). After treatment, the levels of serum TNFα and IL6 in the two groups were significantly lower than those before treatment (P＜005). The observation group was significantly lower than the control group, and the difference was significant (P＜005). There was no significant difference in T lymphocyte subsets between the two groups before treatment (P＞005). After treatment, the levels of CD+ 4and CD+4♂ / CD+8♂ in the two groups were significantly higher than those before treatment (P＜005). The observation group was significantly higher than the control group, and the difference was significant (P＜005). After treatment, the levels of CD+8♂ in the two groups were significantly lower than those before treatment (P＜005). The observation group was significantly lower than the control group, and the difference was significant (P＜005). Conclusion The combination of montelukast sodium combined with terbutaline in the treatment of children with CVA can improve the pulmonary function, inhibit the inflammation of the airway, increase the level of T lymphocyte subsets and promote the recovery of immune function.