【Abstract】 Objective To investigate the effects of liraglutide combined with clomiphene on peripheral blood T cell subsets and oxidative stress of patients with polycystic ovary syndrome (PCOS) and insulin resistance. Methods 92 patients with PCOS and insulin resistance in our hospital from December 2014 to December 2016 were divided into observation group (46 cases) and control group (46 cases). The observation group was treated with liraglutide combined with clomiphene citrate. The control group was treated with clomiphene citrate. Results The total efficiency of the observation group (8261%) was higher than the control group (6087%) (P＜005). BMI and ovarian volume of the two groups decreased after treatment. BMI and ovarian volume of observation group after treatment were lower than that of the control group (t=65840, 115294, P＜005). LH, FSH and T of the two groups reduced after treatment. LH, FSH and T levels after treatment in the observation group were lower than that of control group (t=58437, 70905, 70161, P＜005). FINS and HOMAIR in two groups after decreased after treatment. FINS and HOMAIR after treatment of observation group were lower than that of the control group (t=76955, 78588, P＜005). CD3+ and CD4+/C D8+ of the two groups decreased after treatment. CD3+ and CD4+/CD8+ after treatment of the observation group were lower than that of control group (t=77320, 59132, P＜005). MDA in the observation group was lower than that of the control group and the SOD was higher than that of control group (t=93624, 66042, P＜005). There was no significant difference in the incidence of adverse reactions between the two groups (P＞005). Conclusion Liraglutide combined with clomiphene can get obvious curative effect on polycystic ovary syndrome with insulin resistance, significantly improve blood T lymphocyte subsets and oxidative stress of patients with polycystic ovary syndrome with insulin resistance.