【Abstract】 Vaccination is the centerpiece of preventive care of the well child, which has been one of the singular public health successes of the past half century. Benefited for national immunization program, vaccination has been essential in the control and prevention of infectious diseases in China in the past three decades. Single assess of vaccine by local hygiene serve could not meet the multilevel demand anymore. Exploration for cooperation of multidisciplinary with health administration, and further research of economic evaluations for vaccination programs are needed.