【Abstract】 Objective To ascertain the quantitative value and the range of the diffusion tensor imaging (DTI) parameters of the mild cognitive impairment (MCI) related brain regions and the relationship with clinical cognitive assessment scores. Methods Twenty one MCI patients were enrolled in this study. Ten MCI related brain regions including bilateral hippocampus, parahippocampal gyrus, puposterior cingulate cortices, middle frontal cortices, and middle temporal cortices were selected as the region of interests (ROI). The mean and standard deviation (SD) values of the fractional anisotropy (FA) and mean diffusivity (MD) in each ROI were calculated. Also, the correlation between the mean diffusion parameters and MoCA, MMSE were also analyzed. Results The quantitative mean and SD values of each ROI were obtained. Both MoCA and MMSE scores revealed significant positive correlations with the mean FA value of the right posterior cingulate cortex. Negative correlations were observed between MMSE and the mean FA values of the left hippocampus, right middle frontal cortex, and left middle temporal cortex. Also, the positive correlation were also found between MMSE scores and the MD values in the left hippocampus, left parahippocampal gyrus, right middle temporal cortex. A positive correlation between MMSE scores and the MD values in the left parahippocampal gyrus was also observed. All above correlation results were statistically significant (P＜ 005). Conclusion The quantitative value and the range of FA and MD in cognitive related brain regions may provide significant value for DTI diagnosing to MCI disease. The regions including left hippocampus, left parahippocampal gyrus, right posterior cingulate cortex, right middle frontal cortex, and bilateral middle temporal cortices, which significantly correlated with the clinical assessment score.