【Abstract】 Objective To discuss the diagnosis value of the color doppler ultrasound in KlippelTrenaunay syndrome.Method 59 KTS patients were analyzed. The data of the color Doppler ultrasound diagnoses ranged from January 2014 to January 2017. Femoral vein, superficial femoral vein, deep femoral vein, popliteal vein, great saphenous vein and saphenous vein were detected with high frequency probe. The varicosity of great saphenous vein and saphenous vein, thickening of subcutaneous soft tissue, intraductal thrombosis, absence and variation of deep vein, venous insufficiency and lymphangiectasis were observed.Results All of patients had wide and growth lateral limbs, superficial varicose veins , vena profunda and vena superficialis rami communicans. 29 cases were male in average age 34.5 years. 30 cases were female in average age 26.9 years. Moreover，7 cases hadn't vena profunda.Conclusion It has important clinical application value of the color Doppler ultrasound in KTS diagnoses. It is high sensitive and specific of ultrasound, CT angiography, NMR angiography and so on. Along with widely applying highresolution instrument and highfrequency probe of ultrasound medicine in clinic, the sensitive rate and detection rate of ultrasound vascellum detection is approved.