【Abstract】 Objective To investigate the pathologic feathers, diagnosis, differential diagnosis and prognosis of dendritic fibromyxolipoma ( DFML). Methods We collected three cases of dendritic fibromyxolipoma diagnosed from 2013 to 2015 at the Xin Qiao Hospital of Third Military Medical University. The three cases of dendritic fibromyxolipoma were studied by hematoxylineosin and EliVision immunohistochemical staining. The clinicaland pathological feathers were analyzed with review of the literatures. Results Two of three cases were male, one case was female, with mean age 50 years. The shape of tumor was round or ovoid, and the size of these tumors ranged from 40 cm to 55cm in diameter. They were well circumscribed and encapsulated，with a grayyellow in color and solidgelatinous, soft, myxoid appearance on cut surface. Microscopically, the tumor is mainly consisted of a proliferation of stellate to spindle fibroblasts ,ropelike collagen fibers and varying amount of uneven density mature lipocytes embedded in myxoid stroma. There was a transitional between stellate cells and spindle cells, and with a longthin cytoplasmic dendritic processes. These nucleus chromatin evenly, no obviously cytological atypia or mitotic activity can be identified. Immunohistochemical stain showed that spindle cells and stellate cells were positive for vimentin, CD34 and BCL2 and less than 1% positive rate for Ki67. Conclusion DFML is a rare special variant of lipoma. Its biological behavior is benign, and seems to be misdiagnosed for sarcoma. The pathological histomorphology and immunohistochemistry phenotype are helpful to the diagnosis and differential diagnosis.