Abstract:【Abstract】 Antineutrophil cytoplasmic antibody (ANCA)associated systemic vasculitis Refers to the small blood vessels inflammation and (or) fibrinoid necrosis of the pathological basis of accumulation of multiple organ system of systemic autoimmune diseases.It includes more than granulomatous vasculitis, microscope vasculitis and eosinophilic granulomatous vasculitis.The disease progress rapidly, case fatality rate is high, a serious threat to human health.Monocyte chemotactic protein 1 (MCP 1), also known as the CCL2, is the CC class cell chemotactic factor, of mononuclear macrophages (M &western M phi) have specific chemotaxis and activate the dual role, to participate in the inflammatory process of ANCA associated vasculitis.In this paper, the structure and function of MCP1 and its