【Abstract】 Objective To compare the effect of high energy CO2 dot matrix laser and dot matrix radio frequency in the treatment of atrophic acne scar, to provide references for clinical treatment.Methods Used a prospective study method, From February 2014 to April 2016, 128 patients in our hospital for diagnosis and treatment of atrophic acne scar patients were selected. All the patients were equally divided into the observation group and control group of 64 patients accorded o the order of admission and the principle of random number table. The observation group was given high power CO2 fractional laser treatment. The control group was given dot matrix radio frequency treatment, 1 times / week and were treated five times. The therapeutic effects of the two groups were recorded.Results The total effective rate of the observation group (968%) was significantly higher than that of the control group (859%)(P＜005). The skin lesions in the observation group and control group after treatment were 102±046 points and 167±052 points ,respectively (P＜005) that were significantly lower than before treatment of 345±034 points and 340±041 points, and the observation group was significantly lower than the control group (P＜005). The water loss after treatment in the two groups were significantly reduced and the content was obviously increased that compared before the treatment difference were significant (P＜005). While the observation group after treatment of the water loss and content compared to that of control group were all statistical significance (P＜005). There were no significant difference in the incidence of pain, erythema, pigmentation, and hypertrophic scar compared between the two groups (P＞005).Conclusion Compared with the dot matrix radio frequency, high energy CO2 dot matrix laser application of acne scars can promote the improvement of skin physiological index in, which is conducive to skin symptoms disappear and improve curative effect, and its safety is good that has very good application values.