【Abstract】 According relevant clinical parameters of urinary stones, The urinary calculi secondary to chronic obstructive nephropathy (CON) Risk Model was constructed to verify its applicability.Methods The urinary stones patients in Shiyan Renmin Hospital Affiliated to Hubei University of Medicine Urology from April 2015 to March 2016 for the first time admissions included in this study. The clinical data and laboratory results were analyzed and followup for 18 months to confirm the prognosis. The longterm risk prediction and related risk assessment were analyzed.Results The study included 313 patients with urinary calculi and 280 patients completed followup. 33 patients progressed to CON during followup. Cox regression analysis showed that the risk of poor prognosis in patients with urinary calculi was determined by surgical complications, postoperative recurrence, high urine Neutrophil gelatinase associated lipocalin (uNGAL) content, high Cystic C (CysC) content and high Kidney injury molecule1 (uKIM1) content. All patients with urinary calculi were treated with independent risk factors for one year. The patients with uKIM1≥14987 pg / ml or uNGAL≥13822 ng / ml had more severe disease, progression to stage CON shorter time. uKIM1 threshold index had a higher degree of critical judgment efficacy (P＜005 ).Conclusion Surgical complications, postoperative recurrence of stones, uKIM1, uNGAL, CysC are risk factors of urinary calculi patients with secondary CON.