Abstract:【Abstract】 Objective The study aimed to investigate the efficacy of the new moist dressing (Alginate silver ion dressing , Sulfadiazine silver lipid water gel dressing (SSD) and hydrocolloid dressing) for treating infected wounds in the patients with Herpes zoster (HZ). Methods Randomized controlled study design was employed, and the patients suffered from HZ with wound infection were included in the study. All of them were randomly divided into observation and control groups. The observation group was treated with alginate silver ion dressing, sulfadiazine silver lipid water gel dressing (SSD) or hydrocolloid dressing depending on the infected wounds’ situation, and the control group was alternately treated with Aciclovir Ointment and gentamicin on the infected wounds. In addition, both groups were treated with the same dosage of Acyclovir (05g, Q8h, ivgtt). The situation about the infection controlling, skin lesions and pain relief on the 3th, 6th and 9th day after different treatment were observed. Patients’ degree of pain during each treatment and average consumed nursing time in each day during the first 10 days were also be recorded; Results A total of 78 patients were enrolled in the study and divided into two groups, each group consisting of 39 subjects. A better efficiency (Total effective rate: 29(744%) Vs. 20(513%), P<005) was found in the observation group at the 3th day after treatment, and the rate of marked efficacy was higher in the observation group (32(821%) Vs. 18(462%), P<001) at the 6th day. However, no significant difference between both groups was observed at the 9th day. Meanwhile, the proportion of no or slight pain in the observation group was higher than that in the control group (100% Vs.833%) during the first two treatments, and the average daily change dressing time spent in the observation group was less than that in the control group (P=0000). Conclusion The data suggested that the new moist dressing had a better efficacy for infected skin lesions in HZ than traditional methods.It can obviously improve the speed in wounds healing, control the infection of skin, relieve pain and shorten the course of the disease.