【Abstract】 Objective To evaluate the effect of hemoperfusion or continuous blood purification on severe acute pancreatitis complicated with systemic inflammatory response syndrome.Methods 40 patients with SAP were randomly divided into treatment group 1 and treatment group 2（n=20）and control group （n=26）. The control group was received routine treatment. Group 1 was received hemoperfusion treatment. Group 2 were received hemoperfusion and continuous blood purification. Creactive protein, IL6, IL8 were detected with before hemoperfusion or continuous blood purification on 12, 24, 48 hours after treatment. At the same time, APACHE II score and MODS were assessed.Results In the treatment group, Creactive protein, IL6, IL8, APACHE II score and MODS were significantly lower than that in the control group on 12, 24 and 48 hours after therapy (P＜005). The survival rate was significantly higher in the treatment group than in the control group (825% VS 5769%, P＜005).Conclusion Continuous blood purification can effectively reduce the inflammatory mediators of patients with SAP complicated with systemic inflammatory response syndrome. It can obviously improved internal environment disturbances and viscera function failure