【Abstract】Objectives To analyze the curative effect and security of alprostadil combined with alphalipoic acid (ALA) in treatment of earlydiabetic nephropathy．Methods 90 patients with early diabetic kidney disease were divided into control group (45 patients) and treatment group (45 patients). All the patients accepted routine therapy including diabetic diet, blood glucose, blood pressure and blood lipid control. The control group was given alprostadil, while treatment group was treated with alprostadil combined with ALA. Results After treatment, the levels of blood lipid of the two groups were better than those before treatment. The effect of observation group were better than those of the control group (P＜005). There were no significant differences in the levels of BUN and Cr between the two groups compared with that before treatment(P＞005).β2MG and 24h mAlb of the two groups were better than those before treatment. β2MG and 24h mAlb of observation group after treatment were lower than those of the control group (P＜005). Conclusion Alprostadil combined with ALA is effective and safe for patients with early diabetic nephropathy．