【Abstract】objective To analysis the therapeutic effects of transurethral plasmakinetic enucleation of prostate (TPKEP) for benign prostatic hyperplasia (BPH).Methods 236 patients with prostatic hyperplasia were randomly assigned to observation group and control group. One hundred and eighteen patients in control group were treated with transurethral plasmakinetic resection of the prostate (TPKRP), while one hundred eighteen patients in experimental group were treated with TPKEP. The data including operation time, the weight of the enucleated tissue, bleeding volume, bladder irrigation time, retention time of catheterization, complication incidence, residual urine volume (RUV), maximum urinary flow rate (Qmax), the scores of IPSS and QOL were recorded and compared in the two groups.Results The operation time, intraoperative blood loss, complication incidence, retention time of catheterization and bladder irrigation in the observation group were significantly lower than those in the control group (P＜0.05). The weight of prostate tissue in the observation group was heavier than that in the control group(P＜0.05). After treatment, the RUV and the scores of IPSS, QOL of observation group were lower than those in the control group ( P＜0.05), while Qmax and total clinical efficacy of observation group were higher than those in the control group (P＜0.05).Conclusion Compared with TPKRP treatment, TPKEP treatment for patients with BPH can significantly improve clinic efficacy and reduce the rate of surgical complications.