【Abstract】objective To investigate the effect of local citrate anticoagulation and systemic heparin anticoagulation on the treatment of continuous renal replacement therapy (CRRT) in patients with acute renal injury of sepsis.Methods 88 patients with sepsis acute renal injury admitted in our hospital from January 2015 to June 2016 were randomly divided into observation group and control group. CRRT treatment was performed in both groups. In the treatment group, (HCO3) in the control group was compared with that of the control group (P＜005).The levels of renal function, coagulationrelated index and bicarbonate ion (HCO3) in the control group were significantly higher than those in the control group Comparison of the two groups of patients with filter life. Results After treatment, the Scr and BUN levels of both groups were lower than those before treatment, and the Scr and BUN levels of the patients after treatment were lower than those in the control group (P＜005). APTT and PT after treatment of the two groups were increased. PLT before the treatment reduced. APTT and PT of observation group after treatment were significantly lower than that of control group after treatment. PLT of observation group was significantly higher than control group after treatment (P＜005). There was no significant difference of HCO3concentration between the observation group and the control group before and after treatment (P＜005). Compared with that of the control group, the life expectancy of the filter in the observation group was significantly prolonged (P＜005).Conclusion In the treatment of CRRT, local anticoagulation with citric acid is more effective than systemic heparin anticoagulation in patients with septic acute kidney injury, and which can significantly improve the renal function and prolong the life of the filter