【Abstract】Objective To investigate the effect between the level of serum homocysteine and serum uric acid in Parkinson’s disease.Methods 50 patients with Parkinson’s disease were chosen as cases of illness group. The control group included 50 healthy persons (normal control group) with age and gender matched with PD group. We used the Automatic biochemistry analyzer to examinate the level of serum homocysteine and serum uric acid between the Parkinson’s disease group and control group.Results The level of serum homocysteine in PD group (2204±211μmol/l) was significantly higher than that of Normal control group(1253±109μmol/l). The statistics has significantly difference (P＜005）. The serum uric acid levels in Parkinson’s disease group were significantly lower than those in normal control group (P＜005）. Conclusion Hyperhomocysteinemia and lower serum uric acid levels may be the risk factor of Parkinson’s disease. They will become one of the auxiliary diagnostic indicators.