高效抗逆转录病毒治疗联合化疗对HIV合并肺癌患者骨髓抑制和生存质量评分的影响
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上海市卫生计生委科研项目(201440609);上海市科技创新行动计划医学引导类项目(14411970600)


Effect of highly effective antiretroviral therapy combined with chemotherapy on bone marrow suppression and quality of life scores in patients with human immunodeficiency virus infection in lung cancer
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    摘要:

    【摘要】 目的 探究高效抗逆转录病毒治疗(Highly Active AntiRetroviral Therapy,HAART)联合化疗对人类免疫缺陷病毒(HIV)合并肺癌患者的骨髓抑制及生存质量评分的影响。方法 筛选上海市公共卫生临床中心 2011年1月~2015年10月收治的HIV合并肺癌的30例患者,随机分为两组,分别选择高效抗逆转录病毒治疗联合化疗组患者15例和单纯化疗组患者15例。治疗周期结束后对患者的疗效及不良反应进行评价与统计;按照骨髓抑制程度根据世界卫生组织抗癌药物急性及亚急性毒性反应分度标准进行评价;对病人进行功能状态评分(Karnofsky评分,KPS评分)。结果 治疗周期结束后HAART联合化疗组患者骨髓抑制及生存质量评分均明显高于单纯化疗组的患者(P<005)。结论 对于HIV合并肺癌患者,HAART联合化疗能有效提高临床疗效和患者生活质量,但也是骨髓抑制的高危因素,故应采取针对性的控制措施,可降低骨髓抑制的发生。

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    【Abstract】 Objective To explore the Effect of highly effective antiretroviral therapy combined with chemotherapy on Bone marrow suppression and quality of life scores in patients with HIV infection in lung cancer. Methods The researchers screened 30 patients with HIV infection complicated with lung cancer from January 2011 to October 2015 in Shanghai public health clinical center. 30 patients were divided into HAART therapy combined chemotherapy group (n=15) and chemotherapy group (n=15). The efficacy and adverse reactions of the patients after the end of the treatment cycle were evaluated and statistically evaluated. According to the degree of inhibition of bone marrow, the researchers evaluated the degree of acute and subacute toxicity of the WHO. The researchers evaluated the functional status of the subjects (the Karnofsky score). Results After the implementation of the corresponding treatment, bone marrow suppression and KPS score of the patients treated with HAART combined chemotherapy group were significantly higher than those in the chemotherapy group (P<005). Conclusion For patients with HIV infection in lung cancer, HAART therapy combined with chemotherapy can improve the quality of life of patients, but also the risk factors of bone marrow suppression, and take targeted control measures to reduce the incidence of bone marrow suppression.

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  • 在线发布日期: 2018-01-18
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