【Abstract】〓Gut Microbiota are key components of human body. And the complex intestinal microbial ecology is closely related with immune system of organisms. Intestinal microbes have a significant effect on extraintestinal immune system, innate immunity, specific immunity and even autoimmune diseases. Physicochemical and biological stimulus from outside or our body can break the dynamic equilibrium between normal intestinal microflora and human organisms, resulting in the change of intestinal flora varieties and quantities. Intestinal disorder may plays an important role in the formation of a variety of immune diseases.