Abstract:【Abstract】〓Objective〓To observe the clinical effect of cinobufotalin capsule combined with XELOX chemotherapy in treatment of advanced colorectal cancer. Methods〓 96 advanced colon cancer patients were divided into observation group and control group. The observation group (48 cases) was treated with XELOX chemotherapy, and oral cinobufotalin capsule. The control group was treated with XELOX chemotherapy. The shortterm effective rate, quality of life and adverse reaction were observed. Results〓 The disease control rate of observation group (917%) was higher than that of control group (688%) (P<0001). The improvement rate of quality of life of observation group and control group were 875% and 688% (P<001). The adverse reaction in observation group was significantly reduced compared with that of the control group (P<005). Conclusion〓 The cinobufotalin capsule combined with XELOX chemotherapy for advanced colon cancer can significantly improve the disease control rate and quality of life of patients, and reduce the adverse reaction of chemotherapy.