【Abstract】〓Objective〓To investigate the relationship between dyslipidemia and stroke in patients undergoing maintenance hemodialysis. Methods〓98 patients undergoing maintenance hemodialysis in our hospital from January 2014 to December 2016 were enrolled in the study. All patients underwent CT scan after admission. According to whether the patients had stroke, they were divided into the combination group and the noncombination group, 49 cases in each group. The general data and blood lipids including triglyceride (TG), serum total cholesterol (TC), lowdensity lipoprotein (LDL), highdensity lipoprotein (HDL) were compared between the two groups, and the relationship between dyslipidemia and stroke in patients undergoing maintenance hemodialysis was analyzed. Results〓The constituent ratios of patients with hypertension and patients with diabetes in the combination group were significantly higher than that in the noncombination group. The average age of hemodialysis, diastolic blood pressure and systolic blood pressure of the combination group were significantly higher than those of the noncombination group. TG, TC and LDL in the combination group were significantly higher than that in noncombination group, but HDL level in the combination group was significantly lower than that in the noncombination group (P < 005). Multivariate Logistic analysis showed that hypertension and dyslipidemia were independent risk factors for stroke in patients undergoing maintenance hemodialysis (P < 005). Spearman correlation analysis showed that stroke in patients undergoing maintenance hemodialysis was significantly positively correlated with hypertension and dyslipidemia (r1=6321, r2=7157, P < 005), but it has no correlation with gender, age and fluctuation of blood pressure (r3=1021, r4=2011, r5=2857, P > 005). Conclusion〓There are significant correlations of occurrence, development of stroke and hypertension, dyslipidemia in patients undergoing maintenance hemodialysis, which can be used for developing safe and effective intervention measures and is of important clinical significance to reducing the mortality and ensuring the good prognosis of patients undergoing maintenance hemodialysis.