Abstract:【Abstract】〓Objective〓 To explore the atypical clinical characteristics of children with hand, foot and mouth disease and the correlation of different intestinal virus serotype. Methods〓 The clinical data of 94 children with atypical hand, foot and mouth disease were analyzed. The patients included acra group (lesions mainly distributed in acromegaly), diffusion group (disease spread to the trunk), and coxsackie eczema group (eczema lesions). Mann Whitney nonparametric test data and Fisher's exact test were analyzed. Results〓94 patients were detected with all the genotyping of the virus. The constituent ratio of acra group, diffusion group and coxsackie eczema group was 62%, 15% and 23%. 80% of the patients were with palmoplantar purpura. Coxsackievirus A6 genotype detection rate was 8191% (77/97). According to the date of onset, atypical HFMD common occurred in spring and autumn. Conclusion〓Our prospective study shows that the identification of atypical foot and mouth disease has obvious seasonal, multiple leptospirae, pathogenic analysis further found CA6 and atypical symptoms exist significant correlation. Clinical care of these patients should include symptomatic treatment of extracutaneous features and, if necessary, hospitalization for complications.