【Abstract】Objective To analyze the efficacy and dose of sodium valproate combined with levetiracetam in the treatment of children with epilepsy. Methods 150 children with epilepsy were divided into the sodium valproate group, levetiracetam group and combination group (sodium valproate combined with levetiracetam). The clinical efficacy, EEG efficacy, adverse reactions and changes of cognitive function before and after treatment were compared among the groups. Results The clinical and EEG effective rates of the combination group were 9400% and 8600%, respectively. Compared with those in the sodium valproate group (74.00%, 62.00%), there were significant differences (P＜ 0.05). The EEG efficacy, and total incidence rate of adverse reactions in the levetiracetam group were 80.00% and 10.00%, respectively. Compared with those in the sodium valproate group (62.00%, 32.00%), there were significant differences (P＜0.05). After treatment, the P300 latency in the combination group and the levetiracetam group showed significant difference from that before treatment and that in the sodium valproate group (P＜0.05), and the total score of MoCA also showed significant difference (P＜0.05). After treatment, the P300 latency in the combination group was significantly lower than that in the levetiracetam group (P＜0.05), while the total incidence rate of adverse reactions showed no significant difference (P＞0.05). Conclusion The effect of combination of sodium valproate and levetiracetam is better than monotherapy in the treatment of epilepsy. It can significantly improve the cognitive function of children, without increasing adverse drug reactions, safe and feasible.