Abstract:【Abstract】Objective To explore the effect of hyperbaric oxygen combined with cilostazol on MPV, peripheral nerve conduction velocity and blood viscosity in diabetic foot patients. Methods From January 2015 to August 2016, 70 diabetic foot patients were studied. According to the simple random method were divided into control group and observation group. The control group only received cilostazol treatment. The observation group was treated with cilostazol combined and hyperbaric oxygen. The changes of platelet parameters, peripheral nerve conduction velocity and blood viscosity were compared between the two groups. Results After treatment, the levels of Plt, MPV, PDW and PCT in the two groups were lower than those before treatment(P<0.05). The levels of MPV and PDW in the observation group were significantly lower than those in the control group (P<0.05). The motor and sensory nerve conduction velocity in the two groups were higher than those before treatment(P<0.05), and the motor and sensory nerve conduction velocities in the observation group were higher than those in the control group(P<0.05). The PAG(M), PAG(1 ')%%, Plasma viscosity (100s), beta TG and PF4 before treatment of the two groups were significantly lower than that before treatment(P<0.05). PAG(M), PAG(1')%%, Plasma viscosity(100s), beta, TG PF4 of control group were lower than that of observation group (P<0.05). Conclusion Hyperbaric oxygen combined with cilostazol can effectively reduce platelet parameters and improve the level of peripheral nerve conduction velocity, improve blood viscosity, which has important clinical significance in the treatment of diabetic microangiopathy.