Abstract:【Abstract】Objective To investigate and analyze the relationship between serum free amino acids,bone metabolism related indexes and hyperthyroidism. Methods 68 patients with hyperthyroidism in our hospital from August 2013 to August 2016 were selected as the observation group. 68 healthy persons of physical examination during the same period were selected as the control group.The serum free amino acids and bone metabolism related indexes were compared. The serum free amino acids and bone metabolism related indexes of patients with different basal metabolic rates in observation group were compared, too. Results The observation groups tyrosine, phenylalanine, tryptophan,branched chain amino acid,bone resorption and bone formation indexes were all higher than that of the control group. The other free amino acids of observation group were lower than that of control group. The tyrosine, phenylalanine, tryptophan,branched chain amino acid,bone resorption and bone formation indexes of patients with higher basal metabolic rates in observation group were all higher than the results of patients with lower basal metabolic rates. The other free amino acids of observation group were all lower than the results of patients with lower basal metabolic rates. Conclusion The expression of serum free amino acids,bone metabolism related indexes of patients with hyperthyroidism are abnormal,and the differences of patients with different basal metabolic rates are obvious.