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PD1信号通路在原发性肝癌中的研究进展
林志宇,谢勇久,熊飞,贺庆
0
(乐山市人民医院肿瘤血液科;.四川大学华西医院肿瘤一病房)
摘要:
【摘要】 程序性死亡因子1(programmed death 1, PD1)、 程序性死亡因子1配体( PDL1)与肿瘤发生、发展密切相关, PD1/ PDL1信号通路的激活有助于肿瘤免疫逃逸,而阻断该通路可以减少肿瘤对机体抗肿瘤免疫效应的抑制,更好地发挥人体自身的免疫系统抵御肿瘤的能力,理论上说抗PD1/ PDL1信号通路具有治疗各种类型肿瘤的能力。前期针对PD1/PDL1通路的免疫疗法在晚期恶性黑色素瘤以及非小细胞肺癌中已经获得了令人振奋的效果,故PD1/ PDL1信号通路在原发性肝癌中的应用也值得期待。本文对PD1/PDL1分子信号通路、原发性肝癌中的表达、PD1/PDL1抑制剂在原发性肝癌治疗中的临床研究进行综述,探讨PD1在肝癌治疗的临床应用前景和以后可能发展的方向。
关键词:  PD 1/PD L1信号通路  免疫检测点  原发性肝癌  免疫治疗  研究进展
DOI:
基金项目:四川大学青年科研基金(2016SCU11033)
The progress of PD1 pathway in hepatocellular carcinoma
LIN Zhiyu,XIE Yongjiu,XIONG Fei,HE Qing
(Department of Hematology, Leshan People's Hospital, Leshan;West China Hospital, Sichuan University)
Abstract:
【Abstract】 Programmed cell death 1 (PD1) and its ligand (PDL1) are significantly associate with tumor occurrence and development. It has been proved that PD1 activation contributes to tumor immune escape and PD1/PDL1 inhibitors can restore the activity of T cells, thereby enhance immune response. By this mean, PD1 pathway inhibition should be effect in various tumors and great achievements have been got in nonsmall cell lung cancer and advanced malignant melanoma. So, as a very promising approach in cancer therapy, the application of PD1/PDL1 signal pathway in hepatocellular carcinoma(HCC) is worth looking forward to too. This paper reviews recent basic and clinical advances of PD1 pathway in HCC with the highlights of clinical application of PD1/PDL1 inhibitors and the way of antiPD1 therapy might go in clinic.
Key words:  PD 1/PD L1 signal pathway  Immune check point  Hepatocellular carcinoma  Immunotherapy  Progress

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