【Abstract】 Gastrointestinal tumors occupy an important proportion of malignant tumors. Tumors of distant organ metastasis are one of the main current cancer deaths. Prevent or reduce tumor distant organ metastasis is critical to improve patient survival rate. Currently, there are a lot of influence cancer metastasis researches, the relationship between hypoxia microenvironment and metastasis of cancer researchers at home and abroad has become a hot research. As the tumor vascularity without regularity, making oxygen for tumor central region around the area is poor, the greater the tumor volume, the more obvious differences between this oxygen supply. Hypoxia microenvironment and metastasis of cancer center there is a link, this paper relationship hypoxia microenvironment and metastasis of gastrointestinal cancer were reviewed.