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贝伐珠单抗联合紫杉醇治疗转移性乳腺癌的成本效果分析
胡敏,陈力
0
(1.四川大学华西第二医院药学部/循证药学中心/出生缺陷与相关妇儿疾病教育部重点实验室,2.第三军医大学第二附属医院药学部)
摘要:
【摘要】 目的 从现阶段医疗卫生角度出发,评价四川地区贝伐珠单抗联合紫杉醇治疗转移性乳腺癌的成本效果优势。方法〓根据E2100临床试验数据,结合四川地区医疗费用水平,采用成本效果分析法,以增量成本效果比(ICER)为评价指标,评价贝伐珠单抗联合紫杉醇治疗转移性乳腺癌方案的优劣,并分析结果敏感度。结果〓紫杉醇与贝伐珠单抗联合组与紫杉醇单药组相比,ICER值远远高于3倍GDP;敏感度分析结果提示,当贝伐珠单抗药品费用下降50%时,联合组仍不具有成本效果优势。贝伐珠单抗使用成本和医疗检查成本对总成本影响最大,其他参数影响较小。结论〓从我国现阶段医疗卫生角度出发,四川地区转移性乳腺癌使用贝伐珠单抗联合紫杉醇治疗,尚不具有成本效果优势。
关键词:  贝伐珠单抗  成本 效果  转移性乳腺癌  敏感度分析
DOI:
基金项目:基金项目:四川省科技厅科研项目(15RKX0288)
Cost effectiveness analysis of bevacizumab in combination with paclitaxel for metastatic breast cance
HU Min,CHEN Li
(1.Department of Pharmacy, EvidenceBased Pharmacy Center, Key Laboratory of Birth Defects and Related Diseases of Women and Children in Ministry of Education, West China Second University Hospital, Sichuan University,2. Department of Pharmacy, The Second Affiliated Hospital,The Third Military Medical University)
Abstract:
【Abstract】 Objective To study the costeffectiveness analysis of bevacizumab in combination with chemotherapy for metastatic breast cancer patients in Sichuan Province based on current healthy system of China. Methods According to the result of E2100,we analysed the costeffectiveness by the cost of Sichuan province. Also we would analyse the sensitivity. Results Paclitaxel plus bevacizumab compared with paclitaxel alone, ICER was much higher than three times of the GDP. The sensitivity analysis showed that even if the price of bevacizumab decline 50%, the combination group did not have the costeffectivenss.The price of bevacizumab and the medical examination were the most important among the all parameters about the cost.Conclusion Bevacizumab had not the costeffectiveness in combination with paclitaxel for metastatic breast cancerbased on current healthy system of China.
Key words:  Bevacizumab  Cost effectiveness  Metastatic breast cancer  Sensitivity analysis

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