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胃肠超声造影剂联合静脉超声造影对胃癌的诊断价值
邱伟,陈曙蓓,李明星
0
(内江市第一人民医院超声科;.内江市第二人民医院消化内科;西南医科大学附属医院超声科)
摘要:
【摘要】 目的 探讨自制胃肠超声造影剂联合静脉超声造影对胃癌诊断及T分期的临床价值。方法 采用黑芝麻糊、山药粉作为原材料进行不同的组合,并与“天下牌”胃肠超声造影剂对92例胃肠超声检查患者进行比较,选择最优组合作为胃肠超声造影剂。对经病理检查确诊的151例胃癌患者,于手术前分别行口服自制胃肠超声造影剂胃肠超声检查和在口服自制胃肠超声造影剂的基础上联合静脉超声造影检查,分别做出胃癌的诊断及胃癌T分期的诊断,并与术后病理结果作对比分析。结果 在92例胃肠超声检查患者中,自制胃肠超声造影剂,造影区图像的超声直方图峰位与“天下牌”胃肠超声造影剂相比,差异无显著性(P>0.05)。在151例胃癌患者中,单纯口服自制胃肠超声造影剂胃肠超声检查检出胃癌101例,诊断符合率为66.89 %,胃肠超声双重造影检出胃癌128例,诊断符合率为84.77%。口服自制胃肠超声造影剂胃肠超声检查正确判断T1、T2、T3+T4 期分别为24、46、31例,各期诊断符合率分别为53.33%、70.77%和75.61%。胃肠超声双重造影正确判断T1、T2和T3+T4 期分别为33、56和39例,各期诊断符合率分别约为73.33%、86.15%和95.12%。两者对胃癌术前T分期各期诊断差异均有统计学意义(P<0.05)。结论 自制胃肠超声造影剂可用于对胃部疾病的诊断与静脉超声造影联合运用可明显提高胃癌的诊断率,对T分期具有较高的准确性,可在临床推广应用。
关键词:  自制  胃肠超声造影剂  胃肠超声双重造影  胃癌  T分期
DOI:
基金项目:四川省科技厅泸州市人民政府 泸州医学院2014年联合科研项目,( 14JC0187)
Evaluation of the self made gastrointestinal ultrasound contrast agent combined with intravenous contrast enhanced ultrasound for the diagnosis of gastric cancer
QIU Wei,CHEN Shubei,LI Mingxing
(Department of Ultrasound, The First People’s Hospital of Neijiang;Department of Gastroenterology, The Second People’s Hospital of Neijiang;Department of Ultrasound, The Affiliated Hospital of Southwest Medical University)
Abstract:
【Abstract】 ObjectiveTo explore the value of the selfmade gastrointestinal ultrasound contrast agent combined with intravenous contrast enhanced ultrasound in the diagnosis of gastric cancer and T staging. Methods The commercially available yam powder and black sesame paste were used as raw material. The different combinations were compared with the “TianXia” brand gastrointestinal contrast agent, and the most suitable combination was selected. One hundred and fiftyone patients of gastric cancer diagnosed by pathological examination were performed ultrasonography using oral selfmade gastrointestinal ultrasound contrast agent alone and combined with intravenous contrast enhanced ultrasound. The results of the diagnosis of gastric cancer and T staging were compared with postoperative pathologic findings. Results The ultrasonic contrast zone image histogram peak position of brand black sesame paste combination agents was 20.4±2.3db, and the width was 10.3±1.8db. There was no significant different between brand black sesame paste combination agents and “TianXia” brand gastrointestinal contrast agent. Of the 151 patients, 101 patients were diagnosed with gastric cancer detected by ultrasonography using simple oral selfmade gastrointestinal ultrasound contrast agent, the accuracy rate was 66.89%, and 128 patients were diagnosed with gastric cancer detected by using double contrast gastrointestinal ultrasonography, The accuracy rate was 84.77%. Of the 151 patients underwent gastric cancer, the number of clinical stage T1, T2 and T3+T4 were 45, 65 and 41, respectively. The accuracy number was 24, 46 and 31, respectively in ultrasonography using oral selfmade gastrointestinal ultrasound contrast agent alone group. The total accuracy rate was 66.89%(T1 53.33%, T2 70.77% and T3+T4 75.61%, respectively). The accuracy number was 33, 56 and 39, respectively in double contrast gastrointestinal ultrasound group. The total accuracy rate was 84.77% (T1 73.33%, T2 86.15% and T3+T4 95.12%, respectively). The accuracy rate of double contrast gastrointestinal ultrasound group was higher than ultrasonography using oral selfmade gastrointestinal ultrasound contrast agent alone group (P<0.05). Conclusion The brand black sesame paste combination agent can be used as a gastrointestinal ultrasound contrast agent for the diagnosis of stomach diseases and combined with intravenous contrast enhanced ultrasound had a high accuracy rate of diagnosis of gastric cancer and T staging and it is worth extending in clinical.
Key words:  Self made  Gastrointestinal ultrasound contrast agent  Double contrast gastrointestinal ultrasound  Gastric cancer  T staging

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