引用本文:[点击复制]
[点击复制]
【打印本页】 【在线阅读全文】【下载PDF全文】 查看/发表评论下载PDF阅读器关闭

←前一篇|后一篇→

过刊浏览    高级检索

本文已被:浏览 93次   下载 7 本文二维码信息
码上扫一扫!
儿童紫癜性肾炎244例的流行病学特征与肾脏受累危险因素分析
杜川,董璇,陈铖,杨柳,王晓雯
0
(华中科技大学同济医学院附属武汉儿童医院儿童肾脏内科;武汉市医疗救治中心结核科;武汉大学人民医院肾内科;武汉大学医院内科)
摘要:
【摘要】目的 探讨244例儿童紫癜性肾炎(HSPN)的流行病学、肾脏受累危险因素及早期预防意义。方法 回顾性分析244例HSPN患儿(研究组)临床资料,记录其流行病学特征(发病年龄、季节分布、发病诱因);将同期入院就诊的210例非HSPN的过敏性紫癜(HSP)患儿纳入对照组,比较两组患儿年龄、性别、发病季节、皮疹反复、抗凝药物使用情况、合并症状(腹痛、消化道出血、关节症状、血管性水肿等)、相关实验室指标检测结果及早期预防情况等差异,经非条件Logistic多元逐步回归分析肾脏受累的危险因素。结果 ①244例HSPN患儿男女性别比为2.2:1;发病年龄以5~10岁者居多(84.4%);春季发病率在四季中最高(52.5%);检出明确发病诱因151例(61.9%),其中因呼吸道感染致病者73例,占总人数的29.9%,其次为食物过敏(13.5%)、微生物感染(11.1%)和药物过敏(7.4%)。②两组患儿发病季节、合并关节症状、血管性水肿及红细胞计数(RBC)、红细胞沉降率(ESR)、血浆纤维蛋白原(FIB)检测结果比较,差异均无统计学意义(P>0.05);非条件Logistic多元逐步回归分析结果显示:年龄、皮疹反复、未使用抗凝药物、未予以早期预防、WBC、消化道出血均为影响HSP患儿肾脏受累的独立危险因素(P<0.05)。结论 儿童HSPN以5~10岁的男性患儿居多,春季发病率较高,呼吸道感染、食物或药物过敏、微生物感染等均可致病,年龄、皮疹反复、未使用抗凝药物、未予以早期预防、WBC、消化道出血等是影响HSP患儿肾脏受累的独立危险因素,需临床医师引起重视。
关键词:  儿童  HSPN  流行病学  危险因素  早期预防
DOI:
基金项目:湖北省卫生厅青年人才项目(QJX2010-47)
Epidemiology, risk factors of renal involvement and significance of early prevention in Henoch Schonlein purpura nephritis
DU Chuan,DONG Xuan,CHEN Cheng,YANG Liu,WANG Xiaowen
(Department of Pediatric Nephrology, Wuhan Children's Hospital Affiliated to Tongji Medical College;Department of Tuberculosis, Wuhan Medical Treatment Center;The First Department of Internal Medicine, The People's Hospital of Wuhan University,;Department of Internal Medicine, Hospital of Wuhan University)
Abstract:
【Abstract】Objective To investigate the epidemiology, risk factors of renal involvement and significance of early prevention in 244 children with Henoch Schonlein purpura nephritis (HSPN). Methods The clinical data of 244 children with HSPN (study group) were retrospectively analyzed, and the epidemiological characteristics (age of onset, seasonal distribution, causes) were recorded. 210 children with nonHSPN were included in the control group. Age, gender, onset season, repeated rashes, use of anticoagulants and complications (abdominal pain, gastrointestinal bleeding, joint symptoms, angioedema, etc.), laboratory indicators and early prevention were compared between the two groups, and the risk factors of renal involvement were analyzed by nonconditional Logistic regression analysis. Results The sex ratio of the 244 children with HSPN was 2.2:1. The common age of onset was 5 ~ 10 years old (84.4%). The incidence was the highest in spring (52.5%). The causes of 151 cases were clear(61.9%), including 73 cases induced by respiratory tract infection diseases (29.9%), followed by food allergy (13.5%), microbial infection (11.1%) and drug allergy (7.4%). There were no significant differences in onset season, joint symptoms, angioedema and the detection results of red blood cell count (RBC), erythrocyte sedimentation rate (ESR) and fibrinogen (FIB) between the two groups (P > 0.05). Nonconditional Logistic multivariate regression analysis showed that age, repeated rashes, without use of anticoagulants and early prevention, white blood cell count (WBC) and gastrointestinal bleeding were the independent risk factors of renal involvement in children with HSP (P<0.05). Conclusion Most children with HSPN are 5 to 10 yearold male children, and the incidence is relatively high in spring. Respiratory infections, food or drug allergies and microbial infection can induce the disease, and age, repeated rashes, without use of anticoagulants and early prevention, WBC and gastrointestinal bleeding are the independent risk factors of renal involvement in children with HSP.
Key words:  Children  HSPN  Epidemiology  Risk factors  Early prevention

用微信扫一扫

用微信扫一扫