【Abstract】Objective To discuss the clinical value of early hypertonic saline liquid resuscitation on acute pancreatitis. Methods 90 patients with AP were randomly divided into control group and observation group, which were treated with Ringer's solution resuscitation and hypertonic saline liquid resuscitation. The recovery effects were observed.Results The total effective rate of observation group (97.73%) was significantly higher than that of control group (75.00%, P<0.05). The intestinal mucosal barrier function of observation group was significantly greater than that of the control group (P<0.05). The incidence of related complications of observation group was significantly lower than that of the control group. The prognosis effect of observation group was better than that of control group (P<0.05).Conclusion The early hypertonic saline liquid resuscitation for acute pancreatitis can obtain better treatment effect, promote the patient's body inflammatory reaction, improve intestinal mucous membrane barrier function and reduce the probability of complications.