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碳酸钙配伍小剂量阿司匹林对妊娠高血压高危产妇血压控制及胎盘和血清中T-bet、GATA-3的影响
谭春梅,吴君,谭红梅,罗希,张静
0
(成都医学院第一附属医院产科)
摘要:
【摘要】目的 探讨碳酸钙配伍小剂量阿司匹林干预后,妊娠高血压高危产妇血压控制及胎盘组织和血清中T-bet、GATA-3的变化情况。方法 将2014年1月~2016年1月间196例妊娠期高血压高危孕妇随机分为观察组和对照组各98例,对照组采用常规指导;观察组采用碳酸钙配伍阿司匹林进行干预;干预前及预产期前一周收集血清样本,产后采集胎盘绒毛组织,使用酶联免疫吸附法检测孕妇胎盘组织及血清中GATA-3及T-bet水平,检测血清中钙离子水平,检测孕妇平均动脉压、舒张压及收缩压,记录孕妇的早产、产后出血等并发症发生情况。结果 预产期前一周观察组孕妇收缩压、舒张压及平均动脉压均显著低于干预前(均P<0.05);预产期前一周观察组收缩压、舒张压及平均动脉压均显著低于对照组(均P<0.05);预产期前一周观察组孕妇血清中Ca2+水平显著高于干预前(P<0.05),预产期前一周观察组血清中Ca2+水平差显著低于对照组(P<0.05);预产期前一周观察组及对照组孕妇血清中T-bet水平显著降低干预前(P<0.05);GATA3水平显著高于对照组(均P<0.05);且预产期前一周两组患者血清中T-bet及GATA3水平差异均有统计学意义(P<0.05);观察组患者胎盘中Tbet水平限制低于对照组(P<0.05),GATA3水平显著高于对照组(P<0.05);观察组患者并发症发生率为2.40%显著低于对照组11.25%(P<0.05)。结论 碳酸钙配伍小剂量阿司匹林干预,可有效扩张血管、控制血压异常,有效改善孕妇血清及胎盘中Tbet、GATA3水平,具有较高的临床应用价值。
关键词:  碳酸钙  阿司匹林  妊娠高血压  血压  T-bet  GATA-3
DOI:
基金项目:成都市卫生科研基金项目(20140631)
Effect of low dose aspirin on blood pressure control and T-bet and GATA-3 in placenta and serum of pregnant women with high blood pressure
TAN Chunme,WU Jun,TAN Hongmei,LUO Xi,ZHANG Jing
(Department of Obstetrics and Gynecology, The First Affiliated Hospital of Chengdu Medical College)
Abstract:
【Abstracts】Objective To investigate the changes of blood pressure control and serum Tbet and GATA3 in high risk pregnant women with high risk of pregnancy induced hypertension by using calcium carbonate combined with low dose aspirin. Methods From January 2014 to January 2016, 196 gestational hypertension risk pregnant women were randomly divided into observation group and control group. The control group received routine guidance. The observation group was treated with calcium carbonate and aspirin intervention. The serum samples before the intervention and a week before the due date were collected. The serum GATA3 and Tbet levels of postpartum placental villi were detected with enzymelinked immunosorbent assay. The serum calcium levels, maternal mean arterial pressure, diastolic blood pressure and systolic blood pressure, premature delivery, postpartum hemorrhage and other complications of pregnant women were recorded. Results The systolic blood pressure, diastolic pressure and mean arterial pressure of one week before the expected date of childbirth of pregnant women in observation group were significantly lower than that before intervention (t=12.349, P<0.05; t=8.492, P<0.05; t=19.378, P<0.05). The systolic blood pressure, diastolic pressure and mean arterial pressure of a week before the due date of the observation group were significantly lower than that of the control group (t =15.283, P<0.05 t=6.984; P<0.05, t=15.932, P<0.05). The maternal serum Ca2+ levels of a week before the due date of observation group were significantly higher than before intervention (t=9.034, P<0.05). The maternal serum Ca2+ levels of a week before the due date of observation group was significantly lower than that of the control group (t=9.842, P<0.05). The level of Tbet a week before the due date of the observation group and control group significantly decreased, compared with that after intervention (t=14.284, P<0.05; t=5.019, P<0.05; GATA3). The difference of Tbet and GATA3 levels a week before the due date of the two groups were statistically different (t=5.203, P<0.05; t=7.892, P<0.05;). Tbet level of the observation group was lower than that of the control group (t=38.942, P<0.05). The level of GATA3 the observation group was significantly higher than that of the control group (t=44.395, P<0.05). The complication rate of observation group (2.40%) was significantly lower than the control group(11.25%,χ2=6.163, P<0.05). Conclusion Calcium carbonate combined with low dose aspirin intervention can effectively expand blood vessels, control blood pressure abnormalities, and effectively improve the level of GATA3 and Tbet in serum and placenta of pregnant women.
Key words:  Calcium carbonate  Aspirin  Pregnancy induced hypertension  Blood pressure

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