Abstract:【Abstracts】Objective To investigate the changes of blood pressure control and serum Tbet and GATA3 in high risk pregnant women with high risk of pregnancy induced hypertension by using calcium carbonate combined with low dose aspirin. Methods From January 2014 to January 2016, 196 gestational hypertension risk pregnant women were randomly divided into observation group and control group. The control group received routine guidance. The observation group was treated with calcium carbonate and aspirin intervention. The serum samples before the intervention and a week before the due date were collected. The serum GATA3 and Tbet levels of postpartum placental villi were detected with enzymelinked immunosorbent assay. The serum calcium levels, maternal mean arterial pressure, diastolic blood pressure and systolic blood pressure, premature delivery, postpartum hemorrhage and other complications of pregnant women were recorded. Results The systolic blood pressure, diastolic pressure and mean arterial pressure of one week before the expected date of childbirth of pregnant women in observation group were significantly lower than that before intervention (t=12.349, P<0.05; t=8.492, P<0.05; t=19.378, P<0.05). The systolic blood pressure, diastolic pressure and mean arterial pressure of a week before the due date of the observation group were significantly lower than that of the control group (t =15.283, P<0.05 t=6.984; P<0.05, t=15.932, P<0.05). The maternal serum Ca2+ levels of a week before the due date of observation group were significantly higher than before intervention (t=9.034, P<0.05). The maternal serum Ca2+ levels of a week before the due date of observation group was significantly lower than that of the control group (t=9.842, P<0.05). The level of Tbet a week before the due date of the observation group and control group significantly decreased, compared with that after intervention (t=14.284, P<0.05; t=5.019, P<0.05; GATA3). The difference of Tbet and GATA3 levels a week before the due date of the two groups were statistically different (t=5.203, P<0.05; t=7.892, P<0.05;). Tbet level of the observation group was lower than that of the control group (t=38.942, P<0.05). The level of GATA3 the observation group was significantly higher than that of the control group (t=44.395, P<0.05). The complication rate of observation group (2.40%) was significantly lower than the control group(11.25%,χ2=6.163, P<0.05). Conclusion Calcium carbonate combined with low dose aspirin intervention can effectively expand blood vessels, control blood pressure abnormalities, and effectively improve the level of GATA3 and Tbet in serum and placenta of pregnant women.