【Abstract】 Objective To study the change of small airways function in children with asthma in remission stage and analyze its significance.Methods From January 2013 to December 2015, 100 children with asthma in remission stage were chosen as study objects. At the same time, 50 healthy children were chosen as control group. All the subjects underwent lung function examination. All children with asthma were followed up for 6 months, and divided into different groups according the frequency and severity of asthmatic attack. The large airways function (FVC, PEF, FEV1 and FEV1/FVC) and small airways function(MMEF75/25, FEF25, FEF50 and FEF75) were compared among different children. Results Compared those with control group, FVC, PEF, FEV1 and FEV1/FVC of asthma children had no significant difference (P＞0.05). The MMEF75/25, FEF25, FEF50 and FEF75 significantly decreased (P＜0.05). The FVC, PEF, FEV1 and FEV1/FVC had no significant difference among different groups asthma children(P＞0.05). The difference of MMEF75/25, FEF25, FEF50 and FEF75 demonstrated statistical significance(P＜0.05). Conclusion Children with asthma in remission stage are still detected impaired small airways function, which demonstrates relativity with asthmatic attack.