【Abstract】Objective To investigate the clinical effect of SIS magnesium alloy absorbable biliary stent in the treatment of patients with malignant obstructive jaundice. Methods 67 patients with malignant obstructive jaundice treated with EBMSD in our hospital were selected and divided into control group and observation group according to the different metal biliary stent. The patients in control group accepted normal Nickel titanium alloy stent while the patients in observation group accepted magnesium alloy absorbable biliary stent. The TBIL, ALT, ALP, AST, DBIL, IBIL of all the patients were detected before and after one week of the operation. The complication after operation, survival rate and drainage unobstructed rate after 6 months were observed. Results The stents placing successful rate of control group was 917% and 93.5% for observation group (P＞0.05). After operation, TBIL, ALT, ALP, AST, DBIL, IBIL of the two groups were better than those before operation and there was no significant difference between the two groups (P＞0.05). On the other hand, more complications was observed in the control groups (P<0.05). After 6 months, the survival rate of observation group was 82.3% and drainage unobstructed rate was 72.4, which were better than those in control group (P<0.05). Conclusion SIS magnesium alloy absorbable biliary stent could improve the liver function and reduce the malignant obstructive jaundice symptoms and longer the life of the patients with malignant obstructive jaundice.