Abstract:【Abstract】 Objective To study the clinical value of portal vein hemodynamics by color Doppler ultrasound for hepatic encephalopathy patients in ICU. Methods 79 hepatic encephalopathy patients in ICU of WestHaven class 3~4 were enrolled including 15 cases of acute liver failure, other 64 cases of severe cirrhosis. The pressure gradient of portalsystemic vein, portal vein diameter (PVD), portal vein velocity (PVV), portal vein flow (PVF), splenic vein diameter (SVD), splenic vein velocity (SVV) and splenic vein flow (SVF) were detected by color Doppler ultrasound The levels of blood ammonia, total bilirubin (TBIL), glutamic pyruvic transaminase (ALT) and albumin (ALB) and the delirium scores were measured and analyzed. Results 61 cases (772%) was effective (effective group) and 18 cases (228%) was not effective (noneffective group). The gender, age, WestHaven classes, etiologies, TIPS proportion and disease course of patients in effective group and noneffective group were no statistical different (P>005). The pressure gradient of portalsystemic vein, PVD, PVF, SVD and SVF in effective group were significantly lower than that in noneffective group (P<005). PVV and SVV in effective group were significantly higher than that in noneffective group (P<005). The levels of blood ammonia, TBIL, ALT and ALB in the two groups were no statistical differences (P>005). The delirium scores in the effective group was lower than that in the noneffective group. Conclusion〓It is more valuable of portal vein hemodynamics changes by color Doppler ultrasound than common liver biochemical indicators for clinical prognosis in hepatic encephalopathy patients.