脑卒中后癫痫的临床特点及相关因素分析
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四川省卫计委科研课题 (150018)


Analysis of related factors and clinical features of epilepsy after stroke
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    【摘要】 目的 探讨脑卒中后癫痫的临床特点及相关因素。方法 选择2008年3月至2016年3月住院的脑卒中患者861例,按年龄、性别、卒中类型、病灶部位、病灶范围、癫痫发生时间及类型进行分组比较,分析脑卒中后癫痫的发生率,临床特点及相关危险因素。结果 脑卒中后继发癫痫62例(占72%);男女发生率分别为73 %、71 %;大于或等于60岁和小于60岁发生率分别为74 %(43/581)、68 %(19/280);缺血性卒中继发癫痫发生率为70%(39/560),出血性卒中继发癫痫发生率为7.6%(23/301);组间比较差异均无统计学意义(P>005)。62例癫痫发作患者中,病灶范围05cm220cm2者16例(258%),2cm25cm2者18例(290%),5cm2以上者28例(452%);病灶在5cm2以上继发癫痫与5cm2以下继发癫痫比较,差异有统计学意义(P<005)。在720例单脑叶卒中患者中,继发癫痫30例,141例多脑叶卒中患者中,继发癫痫32例;多脑叶卒中继发癫痫发生率与单脑叶卒中继发癫痫发生率比较,差异有统计学意义(P<005)。62例癫痫患者卒中病灶位于皮层51例(823%),皮层下 11例(177%);两组间比较差异均有统计学意义(P<005)。早发型癫痫40例(645 %),迟发型癫痫22例(355 %);癫痫发作类型中,单纯部分发作29例(468 %),复杂部分发作9例(145 %),全面强直阵挛发作15例(242 %),部分发作继发全面发作9例(145 %)。结论 脑卒中是中老年人癫痫的常见原因,脑卒中后癫痫发生与卒中类型、患者性别、年龄无关;与病变部位、病变大小有关。且大多在急性期发作;发作类型以单纯部分发作最多见。对卒中后发生癫痫患者要高度重视,应在治疗原发疾病的基础上积极控制癫痫,提高生存率

    Abstract:

    【Abstract】 Objective To investigate the clinical features and related factors of epilepsy after stroke.Methods The age, sex, type of stroke, location of lesion, extent of lesion, time and type of epilepsy were grouped and compared. 861 stroke patients in Pujiang People’s Hospital from March 2008 to March 2016 were statistically analyzed in the incidence, clinical features and related risk factors of epilepsy after stroke. Results Seizures occurred in 62 patients of 861 patients with stroke(72%). The incidence of males and females was 73% and 71%, respectively. The incidence of patients aged 60 years was 74% (43/581) and younger was 68% (19/280). The incidence of epilepsy secondary to ischemic stroke was 70% (39/560). The incidence of epilepsy after hemorrhagic stroke was 76% (23/301). There was no significant difference between the two groups (P> 005). 16 patients (258%) had lesions ranging from 05cm2 to 2cm2, 18 cases (290 %)had lesions ranging from 2cm2 to 5cm2, 28 cases (452%) had focal lesions ranging from 5cm2. There was significant difference between epilepsy with secondary lesion above 5cm2 and secondary epilepsy with less than 5cm2 (P <005). 30 patients had secondary epilepsy. There were 32 patients had secondary epilepsy in 141 patients with multiple lobar stroke. The incidence of epilepsy secondary to multiple lobar stroke was significantly higher than that of single epilepsy (P<005). Among 62 cases with epilepsy, 51 cases (823%)Suffered seizures located in brain cortex. The others were located in subcortex. There had statistical difference between the two groups (P<005). There were 40 cases (645%) with earlyonset epilepsy and 22 cases (355%) had lateonset. In the seizure types, there were 29 cases (468%) with partial seizures, 9 cases (145%) with complicated partial seizures, 15 cases (242%) with generalized tonicclonic seizures, and 9 cases (145%) with partial seizures.Conclusion Stroke is a common cause of epilepsy in middleaged people. The occurrence of epilepsy after stroke is not related to stroke type, sex and age of patients.Seizures is mostly in the acute phase attack. Partial seizures are the most common seizure type. We should attach great importance to Patients with epilepsy after stroke, and be effectively control epilepsy based on the treatment of primary disease, improve survival.

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  • 在线发布日期: 2017-08-03
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