【Abstract】 Objective To evaluate the effect of donepezil combined with basic treatment in delay of elderly patients with dementia and SOD,MDA level,so as to provide the basis for the improvement of patients with senile dementia.Methods214 patients with moderate senile dementia were selected and divided into the routine group and the treatment group (n = 107). The conventional group was given basic treatment. The treatment group used donepezil based on the conventional group. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were detected before and after medication. The patients’daily life, mental state on the ADL table and MMSE table were scored before and after treatment.Results The level of serum SOD,MDA and MMSE, ADL score were no significant different between the two groups (P>005). After treatment, the level of MMSE, SOD and MDA in treatment group was better than that of the conventional group (P<005). The improvement rate of dementia in the treatment group (96.5%) was significantly higher than that in the control group. The treatment group had better disease control and improvement (P<005). Before treatment, the life ability defect assessment was no significant different between the two groups (P>005. After treatment, the life ability of the two groups improved. Conclusion The basic treatment combined with donepezil can improve symptoms and cognitive function of patients with senile dementia.