Abstract:【Abstract】 Objective To compare the clinical outcome of PMMA and CPC in the treatment of osteoporotic vertebral compression fractures (OVCF). Methods 90 OVCF patients treated with percutaneous vertebral plasty (PVP) were divided into control group and observation group. CPC were used as PVP cement in observation group, while PMMA were used in control group. The clinical efficacy, EVOS and ODI score, posterior vertebral heights, kyphosis Cobb angle 7 days after surgery and total and adjacent new vertebral fractures after 1 year were compared between the two groups. ResultsThe clinical effective rate of control group and observation group was not obviously different (P> 005). EVOS score, posterior vertebral heights, kyphosis Cobb angle were significantly improved after treatment in the two groups (P < 005), but the difference was not obvious between the two groups (P> 005). ODI score and new vertebral fractures after 1 year of observation group performed significantly better than that of the control group. Conclusion Both PMMA and CPC can act as good methods for PVP treatment in OVCF, but CPC's recent analgesic effect and longtime support effect are superior to those of PMMA.