Abstract:【Abstract】 Objective To observe the clinical effect of lowmolecularweight heparin sodium combined with Honghua injection on the prevention of deep venous thrombosis (DVT) after operation of lower limb fracture. Methods 158 patients were randomly divided into control group and observation group. 78 cases in control group were treated with lowmolecularweight heparin for two weeks. 80 cases in observation group were treated lowmolecularweight heparin sodium combined with Honghua injection for two weeks. The incidence of DVT, hemorheology and blood coagulation state were measured and compared at two weeks after operation. Results The incidence of DVT in the observation group was lower than that in control group (375% vs 1410%, P <005). Plasma viscosity and the whole blood viscosity (low shear and high shear) in the observation group were significantly lower than that in control group (P <005). The prothrombin time (PT)and activated partial thromboplastin time (APTT) of observation group were significantly higher than control group(P <005). Ddimer in the observation group was significantly lower than that in control group (P <005). There were no obvious adverse reactions in the two groups. Conclusion Treatment of lowmoleculareight heparin sodium combined with honghua injection on postoperative patients with lower limb fracture could significantly reduce the incidence of DVT and improve blood hypercoagulable state.