Abstract:【Abstract】 Objective To observe the clinical efficacy and safety of the two kinds of anterior cervical operation in the treatment of multi segment cervical spondylosis myelopathy patients and provide reference for the selection of operative methods in clinical treatment. Methods 98 multi segment cervical spondylosis myelopathy patients treated by operation in our hospital from March 2013 to June 2015 were retrospectively analyzed. The operation methods included LTTS and SITC. 50 patients were divided into A group treated by the LTTS. 48 patients were divided into B group treated by the SITC. The observed indicators included the operative time, the amount of bleeding in the operation, infection, superior laryngeal nerve and recurrent laryngeal nerve injury, the incidence of internal fixation loosening, the bone graft fusion rate, the change of vertebral height and vertebral curvature and the neurological function improvement rate. Results The operative time and amount of bleeding of B group were significantly less than that of A group (P<005). There were no infections occurred and the clinical manifestation of the injury of the superior laryngeal nerve or the recurrent laryngeal nerve occurred in the two groups. The incidence of loosening of internal fixation of A group and B group were 2600% and 625% (P<005). The bone graft fusion rate of A group and B group were 7800% and 8333% (P>005). Preoperative and postoperative vertebral height of A group were (3211 ± 151) mm and (3618±172) mm. Preoperative and postoperative vertebral height of B group were (3227± 144) mm, (3698± 163) mm. There were no significant differences between the two groups before and after the operation. The vertebral height after operation were significantly improved compared with that before operation (P<005). Preoperative and postoperative vertebral curvature of A group were(441±229)mm and (629±187)mm. Preoperative and postoperative vertebral curvature of B group were(437±218)mm and(618±192)mm. There were no significant differences between the two groups before and after the operation. The postoperative vertebral curvature were significantly improved compared with the preoperative vertebral curvature (P<005). The neurological function improvement rate of A group and B group were (864 ± 92)% and (857 ±106)% (P>005).Conclusion(s) Two kinds of operation methods can obtain satisfactory curative effect. SITC has more advantages for security and operability.