【Abstract】 Objective We used SD rats to replicate human’s lumbar disc degeneration (LDD) and evaluate the effect of Shentong Zhuyu Decoction on factorα(TNFα), interleukin1α(IL1α), interleukin6(IL6) and matrix metalloproteinase3 (MMP3) of rats' lumbar disc degeneration (LDD). Methods 8 monthold male SD rats were randomly divided into normal control group (NC group), blank control group (BC group), western medicine group (NASID group) and experimental group of Shentong Zhuyu Decoction (ST group). According to the specific value converted the adult daily clinical administration, WC group were continued oral administration with diclofenac sodium for 30 days. The ST group were used Shentong Zhuyu Decoction (Zelan Mixture) to intragastric gavage (once a day) for 30 days. The BC group, NASID group and NC group were perfused with the same volume of saline for 30 days. The physiological saline dose was same with the ST group. After 30 days, all animals were killed and removed the rats' lumbar disc tissue. TNFα, IL1α, IL6 and MMP3 secretion level were analyzed with molecular biology method. Results TNFα, IL1α, IL6 and MMP3 levels of NASID group and ST group were lower than that of BC group (P<005). TNFα, IL1α, IL6 and MMP3 levels of ST group were lower than that of NASID group (P<005). Conclusion Shentong Zhuyu Decoction can reduce the expression of TNFα, IL1α and IL6、MMP3 of rats' lumbar disc and postpone the process of its degeneration.